阿达尔
非编码RNA
RNA剪接
清脆的
RNA结合蛋白
基因组编辑
小核仁RNA
Cas9
RNA沉默
基因组
转移RNA
抄写(语言学)
作者
Stephen L. Hajduk,Torsten Ochsenreiter
出处
期刊:RNA Biology
[Informa]
日期:2010-03-01
卷期号:7 (2): 229-236
被引量:71
标识
DOI:10.4161/rna.7.2.11393
摘要
RNA editing in kinetoplastid protozoa is a post-transcriptional process of uridine insertion or deletion in mitochondrial mRNAs. The process involves two RNA species, the pre-edited mRNA and in most cases a trans-acting guide RNA (gRNA). Sequences within gRNAs define the position and extend of mRNA editing. Both mRNAs and gRNAs are encoded by mitochondrial genes in the kinetoplast DNA (kDNA), which consists of thousands of small circular DNA molecules, called minicircles, encoding thousands of gRNAs, catenated together and with a few mRNA encoding larger circles, the maxicircles, to form a huge DNA network. Editing has been shown to result in translatable mRNAs of bona fide mitochondrial genes as well as novel alternatively edited transcripts that are involved in the maintenance of the kDNA itself. RNA editing occurs within large protein-RNA complexes, editosomes, containing gRNA, preedited and partially edited mRNAs and also structural and catalytically active proteins. Editosomes are diverse in both RNA and protein composition and undergoe structural remodeling during the maturation. The compositional and structural diversity of editosomes further underscores the complexity of the RNA editing process.
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