医学
替比夫定
怀孕
乙型肝炎
不利影响
儿科
产科
慢性肝炎
骨矿物
内科学
骨质疏松症
免疫学
病毒
拉米夫定
遗传学
生物
作者
Jin Shang,Huan Liu,Qin Wen,Rili M. Ise,You Tu,Lang Bai,Hong Tang
标识
DOI:10.1016/j.ijid.2021.03.023
摘要
BackgroundLimited data exist regarding the efficacy and long-term safety of nucleos(t)ide analogue therapy throughout pregnancy for women with chronic hepatitis B and their children.MethodsThis retrospective cohort study included 165 women in total: 91 women received telbivudine (LDT) and 74 women received tenofovir (TDF) throughout pregnancy. The virological response and safety in women were recorded, and the physical development and bone mineral density in children were evaluated up to 5 years of age.ResultsThe rate of virological breakthrough in women was 4.24% overall (7.70% in LDT group and 0% in TDF group; P < 0.05). No cases of renal injury or other obstetric adverse events occurred in either group of women. Among the children, only one child had a significantly low Z score for weight for age (<-2), and no children had a significantly low Z score for height for age or bone mineral density. No significant difference was found between the children in the two groups.ConclusionsNucleos(t)ide analogue therapy with TDF or LDT throughout pregnancy had no effect on the long-term physical development and bone development of children. In addition, the use of TDF throughout pregnancy had better long-term antiviral efficacy than LDT in women, with no evidence of renal toxicity.
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