普鲁士蓝
对比度(视觉)
纳米颗粒
磁共振成像
核磁共振
材料科学
锰
相(物质)
生物相容性材料
氧化铁
化学
核化学
纳米技术
物理
生物医学工程
医学
光学
物理化学
放射科
有机化学
电极
冶金
电化学
作者
Murthi S. Kandanapitiye,Thiloka M. Dassanayake,Arosha C. Dassanayake,John Shelestak,Robert J. Clements,C.A.N. Fernando,Songping D. Huang
标识
DOI:10.1002/adhm.202100987
摘要
Abstract The lack of acid stability in the stomach and of temporal stability when moving through the gastrointestinal (GI) tract has made the development of oral magnetic resonance imaging (MRI) contrast agents based on the platform of Gd 3+ –complexes problematic.On the other hand, the negative contrast enhancement produced by the T 2 ‐weighted magnetic metal oxide nanoparticles (NPs) often renders the image readout difficult. Biocompatible NPs of the manganese Prussian blue analog K 2 Mn 3 [Fe II (CN) 6 ] 2 exhibit extremely high stability under the acidic conditions of the gastric juice. Additionally, the high r 1 relaxivity, low toxicity, and high temporal stability of such NPs offer great potential for the development of a true T 1 ‐weighted oral contrast agent for MRI of the entire GI tract.
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