医学
药物输送
中枢神经系统
肌萎缩侧索硬化
纳米医学
疾病
多发性硬化
血脑屏障
药品
神经科学
药物输送到大脑
从长凳到床边
药理学
纳米技术
病理
免疫学
心理学
内科学
材料科学
纳米颗粒
医学物理学
作者
Thuy Trang Nguyen,Thi Thuy Dung Nguyen,Tuong Kha Vo,Tran Nguyen Minh An,Minh Kim Nguyen,Vo Van Toi,Vo Van Giau
标识
DOI:10.1016/j.biopha.2021.112117
摘要
Drug delivery to central nervous system (CNS) diseases is very challenging since the presence of the innate blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier that impede drug delivery. Among new strategies to overcome these limitations and successfully deliver drugs to the CNS, nanotechnology-based drug delivery platform, offers potential therapeutic approach for the treatment of some common neurological disorders like Alzheimer's disease, frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease. This review aimed to highlight advances in research on the development of nano-based therapeutics for their implications in therapy of CNS disorders. The challenges during clinical translation of nanomedicine from bench to bed side is also discussed.
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