亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Connectivity Patterns in the Core Resting-State Networks and Their Influence on Cognition

静息状态功能磁共振成像 显著性(神经科学) 默认模式网络 神经科学 认知 记忆广度 心理学 听力学 工作记忆 任务正网络 功能磁共振成像 认知心理学 医学
作者
Tanja Veselinović,Ravichandran Rajkumar,Laura Amort,Jessica Junger,N. Jon Shah,Bruno Fimm,Irene Neuner
出处
期刊:Brain connectivity [Mary Ann Liebert, Inc.]
卷期号:12 (4): 334-347 被引量:5
标识
DOI:10.1089/brain.2020.0943
摘要

Introduction: Three prominent resting-state networks (rsNW) (default mode network [DMN], salience network [SN], and central executive network [CEN]) are recognized for their important role in several neuropsychiatric conditions. However, our understanding of their relevance in terms of cognition remains insufficient. Materials and Methods: In response, this study aims at investigating the patterns of different network properties (resting-state activity [RSA] and short- and long-range functional connectivity [FC]) in these three core rsNWs, as well as the dynamics of age-associated changes and their relation to cognitive performance in a sample of healthy controls (N = 74) covering a large age span (20-79 years). Using a whole-network based approach, three measures were calculated from the functional magnetic resonance imaging (fMRI) data: amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo), and degree of network centrality (DC). The cognitive test battery covered the following domains: memory, executive functioning, processing speed, attention, and visual perception. Results: For all three fMRI measures (ALFF, ReHo, and DC), the highest values of spontaneous brain activity (ALFF), short- and long-range connectivity (ReHo, DC) were observed in the DMN and the lowest in the SN. Significant age-associated decrease was observed in the DMN for ALFF and DC, and in the SN for ALFF and ReHo. Significant negative partial correlations were observed for working memory and ALFF in all three networks, as well as for additional cognitive parameters and ALFF in CEN. Discussion: Our results show that higher RSA in the three core rsNWs may have an unfavorable effect on cognition. Conversely, the pattern of network properties in healthy subjects included low RSA and FC in the SN. This complements previous research related to the three core rsNW and shows that the chosen approach can provide additional insight into their function. Impact statement Using a whole network-based approach, our study characterizes the normal patterns (including resting-state activity [RSA], short- and long-range functional connectivity [FC]) of three prominent resting-state networks (rsNW) within the context of age-dependent changes and explores their relevance for different cognitive domains. Our results revealed a pattern with low RSA and FC in the salience network in healthy volunteers, whereas higher RSA, particularly in the central executive network, seemed to have a negative effect on cognition. These results increase the knowledge about the three core rsNWs and the understanding about their relevance for cognition.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jiangjiang完成签到 ,获得积分10
21秒前
吱吱草莓派完成签到 ,获得积分10
26秒前
54秒前
小二郎应助科研通管家采纳,获得10
54秒前
59秒前
1分钟前
宝贝丫头完成签到 ,获得积分10
1分钟前
英姑应助背后的鞋垫采纳,获得10
1分钟前
桐桐应助Benhnhk21采纳,获得10
1分钟前
Dave发布了新的文献求助10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
Aaron完成签到 ,获得积分0
3分钟前
3分钟前
5分钟前
Liufgui应助Dave采纳,获得10
5分钟前
Benhnhk21发布了新的文献求助10
5分钟前
yydragen应助yyds采纳,获得10
5分钟前
Hisam完成签到,获得积分10
5分钟前
lhy完成签到,获得积分10
6分钟前
lhy发布了新的文献求助10
6分钟前
6分钟前
积极的台灯应助Benhnhk21采纳,获得10
6分钟前
Hisam发布了新的文献求助10
6分钟前
yyds完成签到,获得积分0
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
木木完成签到 ,获得积分10
6分钟前
7分钟前
董可以发布了新的文献求助10
7分钟前
小马甲应助董可以采纳,获得10
7分钟前
7分钟前
Boren发布了新的文献求助10
7分钟前
梨子完成签到,获得积分10
7分钟前
Boren完成签到,获得积分10
7分钟前
WerWu完成签到,获得积分10
9分钟前
彭于晏应助Dc采纳,获得10
9分钟前
10分钟前
情怀应助科研通管家采纳,获得10
10分钟前
11分钟前
Dc发布了新的文献求助10
11分钟前
Dc完成签到,获得积分10
11分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990290
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805197
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234