医学
纤溶
纤溶酶原激活剂
血栓形成
深静脉
内科学
纤溶酶原激活物抑制剂-1
组织纤溶酶原激活剂
静脉血栓形成
胃肠病学
作者
Saniya Sharma,Varun Uppal,Hari Kishan Senee,Jasmina Ahluwalia,Reena Das,Neelam Varma,Pankaj Malhotra,Narender Kumar
标识
DOI:10.1097/mbc.0000000000001114
摘要
The association of the fibrinolytic markers with deep vein thrombosis (DVT) is still a matter of debate. The present study aimed to investigate the association between fibrinolytic markers and DVT. This observational study recruited 52 adult cases with lower limb DVT and 52 healthy adult volunteers as controls. The quantitative determination of plasminogen activator inhibitor-1 (PAI-1), plasminogen, thrombin activable fibrinolysis inhibitor (TAFI), tissue plasminogen activator (tPA) and α2-antiplasmin (α2-AP) was performed by ELISA. TAFI, plasminogen and t-PA were significantly higher in cases than controls and PAI-1 was significantly lower in cases than controls. In addition, TAFI, plasminogen and t-PA levels were significantly increased in unprovoked and idiopathic DVT cases than controls. The present study suggests that the fibrinolytic markers tested in patients with a remote history of DVT are different than in individuals with no history of DVT and, with further study, may prove useful as screening assays for DVT risk.
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