The differences between daytime and night-time heart rate variability may usefully predict the apnea-hypopnea index in patients with obstructive sleep apnea

The association between daytime/night-time heart rate variability (HRV) and the apnea-hypopnea index (AHI) remains unclear. We sought a relationship between AHI and the daytime-to night-time HRV ratio as measured by 24-h Holter monitoring in patients with obstructive sleep apnea (OSA).We prospectively enrolled 66 patients who visited our sleep clinic complaining of habitual snoring or sleep apnea. All underwent 24-h Holter monitoring (to measure HRV) combined with full-night polysomnography (PSG). Sixty-two met our enrolment criteria. We evaluated the associations between HRV frequency domains and the PSG indices. We also considered medical histories and anthropometric data.The night-time very low frequency (VLF), low frequency (LF), and high frequency (HF) HRVs were significantly higher than the daytime values. On correlation analysis, the day/night VLF (r = 0.550, p < 0.001), LF (r = 0.556, p < 0.001), and HF (r = 0.303, p = 0.017) HRVs were significantly related to the AHI. Of the day/night HRV ratios, the VLF (p for trend = 0.003) and LF (p for trend = 0.013) ratios decreased significantly by OSA severity. Multivariable analysis showed that the day/night VLF (β = 16.387, p < 0.001) and day/night LF (β = 25.248, p < 0.001) were independently (and significantly) associated with the AHI.Twenty-four-hour Holter monitoring may usefully predict AHI. The day/night VLF and day/night LF ratios tended to decrease by OSA severity and were independently associated with the AHI.