医学
恶性肿瘤
肝移植
治疗
放射科
放化疗
内镜超声
化疗
入射(几何)
内科学
放射治疗
外科
移植
疾病
光学
物理
作者
Shahid A. Khan,Howard Thomas,Brian R. Davidson,Simon D. Taylor‐Robinson
出处
期刊:The Lancet
[Elsevier]
日期:2005-10-01
卷期号:366 (9493): 1303-1314
被引量:965
标识
DOI:10.1016/s0140-6736(05)67530-7
摘要
Cholangiocarcinoma is a devastating malignancy that presents late, is notoriously difficult to diagnose, and is associated with a high mortality. The incidence of intrahepatic cholangiocarcinoma is increasing worldwide. The cause for this rise is unclear, although it could be related to an interplay between predisposing genetic factors and environmental triggers. MRI and CT with endoscopic ultrasound and PET provide useful diagnostic information in certain patients. Surgical resection is the only chance for cure, with results depending on careful technique and patient selection. Data suggest that liver transplantation could offer long-term survival in selected patients when combined with neoadjuvant chemoradiotherapy. Chemotherapy and radiotherapy have been ineffective for patients with inoperable tumours. For most of these patients biliary drainage is the mainstay of palliation. However, controversy exists over the type and positioning of biliary stents. Photodynamic treatment is a new palliative technique that might improve quality of life.
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