Fanconi Syndrome

Fanconi syndrome , also known as the DeToni, Debré, Fanconi syndrome is a global dysfunction of the proximal tubule characterized by glucosuria , phosphaturia , generalized aminoaciduria , and type II renal tubular acidosis. Often there is hypokalemia , sodium wasting, and dehydration. In children, it typically is caused by inborn errors of metabolism , principally cystinosis . In adults, it is mainly caused by medications, exogenous toxins, and heavy metals. Treatment consists of treating the underlying cause and replacing the lost electrolytes and volume.