结肠炎
炎症性肠病
促炎细胞因子
发病机制
失调
肠道菌群
溃疡性结肠炎
益生菌
发酵
化学
微生物学
食品科学
免疫学
生物
细菌
炎症
疾病
医学
生物化学
内科学
遗传学
作者
Hyeon-Ji Lim,Ha-Rim Kim,Su-Ji Jeong,Hee-Jong Yang,Myeong Seon Ryu,Do-Youn Jeong,Seon-Young Kim,Chan-Hun Jung
出处
期刊:Foods
[MDPI AG]
日期:2022-03-08
卷期号:11 (6): 776-776
被引量:5
标识
DOI:10.3390/foods11060776
摘要
Inflammatory bowel disease (IBD) is a chronic inflammatory disease, and the incidence of IBD is increasing every year owing to changes in dietary structure. Although the exact pathogenesis of IBD is still unclear, recent evidence suggests that gut dysbiosis is closely associated with IBD pathogenesis. Cheonggukjang is a traditional Korean fermented soybean paste produced using traditional and industrial methods, and contains probiotics, which affect the gut microbiota composition. However, the protective effect of Cheonggukjang against IBD is unknown. In this study, we investigated the bacterial community structure of traditional and commercial Cheonggukjang samples, as well as the protective effect of Cheonggukjang on a dextran sulfate sodium (DSS)-induced colitis mouse model. Traditional and commercial Cheonggukjang were found to contain various type of useful probiotics in their bacterial community structure. Cheonggukjang reduced the progression of DSS-induced symptoms, such as body weight loss, colonic shortening, disease activity index, and histological changes. Further, Cheonggukjang improved the intestinal epithelial barrier integrity on DSS-induced colitis mice. In addition, Cheonggukjang suppressed the expression of proinflammatory cytokines and inflammatory mediators through the inactivation of NF-κB and MAPK signaling pathways. These results indicate that Cheonggukjang exerts protective effects against DSS-induced colitis, suggesting its possible application as a functional food for improving inflammatory diseases.
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