Splenectomy ameliorates portal pressure and anemia in animal models of cirrhotic and non-cirrhotic portal hypertension

医学 门脉高压 脾切除术 门静脉压 高动力循环 胃肠病学 内科学 血压 血小板增多症 肝硬化 外科 血小板 脾脏
作者
Philipp Schwabl,Berit Seeland,Florian Riedl,Tim Lukas Schubert,Philipp Königshofer,Ksenia Brusilovskaya,Oleksandr Petrenko,Benedikt Hofer,Ana‐Iris Schiefer,Michael Trauner,Markus Peck‐Radosavljevic,Thomas Reiberger
出处
期刊:Advances in Medical Sciences [Elsevier]
卷期号:67 (1): 154-162 被引量:10
标识
DOI:10.1016/j.advms.2022.02.005
摘要

Portal hypertension (PH)-associated splenomegaly is caused by portal venous congestion and splanchnic hyperemia. This can trigger hypersplenism, which favors the development of cytopenia. We investigated the time-dependent impact of splenectomy on portal pressure and blood cell counts in animal models of non-cirrhotic and cirrhotic PH.Ninety-six rats underwent either partial portal vein ligation (PPVL), bile duct ligation (BDL), or sham operation (SO), with subgroups undergoing additional splenectomy. Portal pressure, mean arterial pressure, heart rate, blood cell counts and hemoglobin concentrations were evaluated throughout 5 weeks following surgery.Following PPVL or BDL surgery, the animals presented a progressive rise in portal pressure, paralleled by decreased mean arterial pressure and accelerated heart rate. Splenectomy curbed the development of PH in both models (PPVL: 16.25 vs. 17.93 ​mmHg, p ​= ​0.083; BDL: 13.55 vs. 15.23 ​mmHg, p ​= ​0.028), increased mean arterial pressure (PPVL: +7%; BDL: +9%), and reduced heart rate (PPVL: -10%; BDL: -13%). Accordingly, splenectomized rats had lower von Willebrand factor plasma levels (PPVL: -22%; BDL: -25%). Splenectomy resulted in higher hemoglobin levels in PPVL (14.15 vs. 13.08 ​g/dL, p ​< ​0.001) and BDL (13.20 vs. 12.39 ​g/dL, p ​= ​0.097) animals, and significantly increased mean corpuscular hemoglobin concentrations (PPVL: +9%; BDL: +15%). Thrombocytopenia only developed in the PPVL model and was alleviated in the splenectomized subgroup. Conversely, BDL rats presented with thrombocytosis, which was not affected by splenectomy.Splenectomy improves both cirrhotic and non-cirrhotic PH, and ameliorates the hyperdynamic circulation. Hypersplenism related anemia and thrombocytopenia were only significantly improved in the non-cirrhotic PH model.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
梵高完成签到,获得积分10
刚刚
一秋一年完成签到,获得积分10
1秒前
沉梦志昂完成签到,获得积分10
1秒前
风再起时应助17686418536采纳,获得20
2秒前
nnnnnn发布了新的文献求助10
2秒前
3秒前
3秒前
小菜白完成签到,获得积分10
3秒前
一秋一年发布了新的文献求助10
4秒前
hanhan完成签到,获得积分20
5秒前
yang完成签到,获得积分10
5秒前
6秒前
MMM完成签到,获得积分10
6秒前
hhh发布了新的文献求助10
7秒前
7秒前
疯丫头完成签到,获得积分10
7秒前
fifteen应助zq采纳,获得10
8秒前
8秒前
LIKO完成签到,获得积分10
8秒前
wnche完成签到,获得积分10
8秒前
11完成签到,获得积分10
9秒前
yesdanny完成签到,获得积分10
9秒前
图图完成签到 ,获得积分10
10秒前
11秒前
四小时充足睡眠完成签到,获得积分10
11秒前
bohn123完成签到 ,获得积分10
11秒前
1124发布了新的文献求助10
11秒前
tzy完成签到,获得积分10
11秒前
酷炫翠桃应助Singularity采纳,获得10
12秒前
陈嘻嘻嘻嘻完成签到,获得积分10
12秒前
12秒前
13秒前
HR112发布了新的文献求助30
13秒前
端庄的访卉完成签到 ,获得积分10
13秒前
yilin发布了新的文献求助10
14秒前
若水三千发布了新的文献求助10
14秒前
xue发布了新的文献求助30
14秒前
lmwnb完成签到,获得积分10
14秒前
天天快乐应助向前采纳,获得10
15秒前
fddsfs发布了新的文献求助10
15秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3253464
求助须知:如何正确求助?哪些是违规求助? 2896017
关于积分的说明 8289700
捐赠科研通 2564792
什么是DOI,文献DOI怎么找? 1392561
科研通“疑难数据库(出版商)”最低求助积分说明 652230
邀请新用户注册赠送积分活动 629544