Flow separation devices are important for flow syntheses as they offer simple in-line methods to remove intermediates or impurities. They can also be used for solvent and catalyst recovery. Two major flow separation technologies will be discussed in this chapter: adsorption/scavenger and liquid–liquid extraction. Their principles and examples in flow chemistry are described. In particular, three main types of continuous extraction equipment, including membrane-based, mixer-settler, and columns, are overviewed.