纳米反应器
高尿酸血症
化学
红细胞
尿酸氧化酶
催化作用
尿酸
生物化学
作者
Jiang Ming,Tianbao Zhu,Jingchao Li,Zichen Ye,Changrong Shi,Zhide Guo,Jingjuan Wang,Xiaolan Chen,Nanfeng Zheng
出处
期刊:Small
[Wiley]
日期:2021-10-19
卷期号:17 (46)
被引量:40
标识
DOI:10.1002/smll.202103645
摘要
Nanozyme-based cascade reaction has emerged as an effective strategy for disease treatment because of its high efficiency and low side effects. Herein, a new and highly active two-dimensional Pd-Ru nanozyme is prepared and then integrated with uricase and red blood cell (RBC) membrane to fabricate a tandem nanoreactor, Pd-Ru/Uricase@RBC, for hyperuricemia treatment. The designed Pd-Ru/Uricase@RBC nanoreactor displayed not only good stability against extreme pH, temperature and proteolytic degradation, but also long circulation half-life and excellent safety. The nanoreactor can effectively degrade UA by uricase to allantoin and H2 O2 and remove H2 O2 by using Pd-Ru nanosheets (NSs) with the catalase (CAT)-like activity. More importantly, the finally produced O2 from H2 O2 decomposition can in turn facilitate the catalytic oxidation of UA, as the degradation of UA is an O2 consumption process. By integrating the high-efficiency enzymatic activity, long circulation capability, and good biocompatibility, the designed Pd-Ru/Uricase@RBC can effectively and safely treat hyperuricemia without side effects. The study affords a new alternative for the exploration of clinical treatment of hyperuricemia.
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