化学
光催化
背景(考古学)
化学空间
生化工程
表面改性
纳米技术
药物发现
有机化学
工程类
催化作用
生物化学
生物
物理化学
古生物学
材料科学
作者
Lisa Candish,Karl D. Collins,Gemma C. Cook,James J. Douglas,Adrián Gómez‐Suárez,Anaïs Jolit,Sebastian Keeß
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-09-24
卷期号:122 (2): 2907-2980
被引量:221
标识
DOI:10.1021/acs.chemrev.1c00416
摘要
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science industry require access to mild and robust synthetic methodologies to systematically modify chemical structures, explore novel chemical space, and enable efficient synthesis. In this context, photocatalysis has emerged as a powerful technology for the synthesis of complex and often highly functionalized molecules. This Review aims to summarize the published contributions to the field from the life science industry, including research from industrial-academic partnerships. An overview of the synthetic methodologies developed and strategic applications in chemical synthesis, including peptide functionalization, isotope labeling, and both DNA-encoded and traditional library synthesis, is provided, along with a summary of the state-of-the-art in photoreactor technology and the effective upscaling of photocatalytic reactions.
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