Clinical Mass Spectrometry Approaches to Myeloma and Amyloidosis

The diagnosis of myeloma and other plasma cell disorders has traditionally been done with the aid of electrophoretic methods, whereas amyloidosis has been characterized by immunohistochemistry. Mass spectrometry has recently been established as an alternative to these traditional methods and has been proved to bring added benefit for patient care. These newer mass spectrometry–based methods highlight some of the key advantages of modern proteomic methods and how they can be applied to the routine care of patients.