尼奥体
伤口愈合
纤维连接蛋白
活力测定
药理学
体外
透明质酸
化学
医学
小泡
细胞
外科
生物化学
膜
解剖
作者
Teerasak Damrongrungruang,Jarin Paphangkorakit,Sucharat Limsitthichaikoon,Bhattaranitch Khampaenjiraroch,Michael J. Davies,Bunleu Sungthong,Aroonsri Priprem
标识
DOI:10.1016/j.nano.2021.102423
摘要
An anthocyanin complex (AC), composed of extracts of purple waxy corn and blue butterfly pea petals, and AC niosomes, bilayered vesicles of non-ionic surfactants, were compared in in vitro and clinical studies. Cultured fibroblasts subjected to a scratch wound were monitored for cell viability, cell migration, nuclear morphology and protein expression. Scratched cells showed accelerated wound healing activity, returning to normal 24 h after treatment with AC niosomes (0.002 mg/mL). Western blots and immunocytochemistry indicated upregulation of type I, III and IV collagens, fibronectin and laminins in AC niosome-treated scratched cells. A randomized block placebo-controlled double-blind clinical trial in 60 volunteers (18-60 years old) with oral wounds indicated that AC niosome gel accelerated wound closure, reduced pain due to the oral wounds and improved participants' quality of life more than AC gel, triamcinolone gel and placebo gel. These data are consistent with enhanced delivery of AC to fibroblasts by use of niosomes. AC niosomes activated fibroblasts within wounded regions and accelerated wound healing, indicating that AC niosomes have therapeutic potential.
科研通智能强力驱动
Strongly Powered by AbleSci AI