VP10-2021: Cabozantinib (C) plus atezolizumab (A) versus sorafenib (S) as first-line systemic treatment for advanced hepatocellular carcinoma (aHCC): Results from the randomized phase III COSMIC-312 trial
Robin Kate Kelley,Thomas Yau,Ann‐Lii Cheng,Ahmed O. Kaseb,Shukui Qin,Andrew X. Zhu,Stephen L. Chan,Wattana Sukeepaisarnjaroen,В. В. Бредер,Gontran Verset,Edward Gane,Ivan Borbath,J.D. Gomez Rangel,Philippe Merle,Fawzi Benzaghou,Kamalika Banerjee,Saswati Hazra,Jonathan W. Fawcett,Lorenza Rimassa
The multikinase inhibitor C has shown promising clinical activity in combination with immune checkpoint inhibitors, including A, in multiple tumor types. COSMIC-312 (NCT03755791) is evaluating C+A vs S as first-line systemic treatment for aHCC.