鞘氨醇
细胞生物学
川地69
下调和上调
效应器
记忆T细胞
刺激
受体
免疫系统
生物
CD8型
T细胞
1-磷酸鞘氨醇
免疫受体
化学
白细胞介素2受体
免疫学
内分泌学
生物化学
基因
作者
Laura K. Mackay,Asolina Braun,Bethany MacLeod,Nicholas Collins,Christina Tebartz,Sammy Bedoui,Francis R. Carbone,Thomas Gebhardt
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2015-01-27
卷期号:194 (5): 2059-2063
被引量:420
标识
DOI:10.4049/jimmunol.1402256
摘要
Abstract Tissue-resident memory T cells provide local immune protection in barrier tissues, such as skin and mucosa. However, the molecular mechanisms controlling effector T cell retention and subsequent memory formation in those locations are not fully understood. In this study, we analyzed the role of CD69, an early leukocyte activation marker, in regulating effector T cell egress from peripheral tissues. We provide evidence that CD69 surface expression by skin-infiltrating CD8 T cells can be regulated at multiple levels, including local Ag stimulation and signaling through type I IFNRs, and it coincides with the transcriptional downregulation of the sphingosine-1-phosphate receptor S1P1. Importantly, we demonstrate that expression of CD69, by interfering with sphingosine-1-phosphate receptor function, is a critical determinant of prolonged T cell retention and local memory formation. Our results define an important step in the generation of long-lived adaptive immune memory at body surfaces.
科研通智能强力驱动
Strongly Powered by AbleSci AI