Development of a new electrochemical imprinted sensor based on poly-pyrrole, sol–gel and multiwall carbon nanotubes for determination of tramadol

碳纳米管 材料科学 电化学气体传感器 介电谱 聚吡咯 分子印迹聚合物 循环伏安法 电极 电化学 检出限 化学工程 分析化学(期刊) 纳米技术 聚合物 复合材料 色谱法 化学 聚合 选择性 有机化学 催化作用 物理化学 工程类
作者
Behjat Deiminiat,Gholam Hossein Rounaghi,Mohammad Hossein Arbab-Zavar
出处
期刊:Sensors and Actuators B-chemical [Elsevier BV]
卷期号:238: 651-659 被引量:102
标识
DOI:10.1016/j.snb.2016.07.110
摘要

A novel electrochemical imprinted sensor was constructed for sensitive and selective determination of tramadol (TRA) by combination of a functionalized multiwall carbon nanotubes (f-MWCNTs) layer and a thin molecularly imprinted film. The imprinted sensor was fabricated on the surface of a glassy carbon electrode (GCE) through layer by layer modification of f-MWCNTs and a thin film of molecularly imprinted polymer (MIP) composed of polypyrrole (PPy), sol–gel and tramadol by electrochemical deposition. Multiwall carbon nanotubes (MWCNTs) were introduced for the enhancement of electronic transmission and sensitivity. Electrochemical methods including cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to characterize the processes of electropolymerization, template removal and rebinding in the presence of [Fe(CN)6]3−/[Fe(CN)6]4− which was used as an electrochemical active probe. The effect of several parameters influencing the performance of the imprinted sensor, were investigated and optimized. Under the optimized experimental conditions, the calibration curve of the MIP electrode had two linear concentration ranges from 0.2 to 2.0 nM and 2.0–20.0 nM, with a limit of detection (LOD) of 0.03 nM. The effects of interfering substances on the determination of tramadol were also investigated and it was found that the proposed sensor is highly selective to tramadol. Also, the reproducibility, repeatability, stability and the response time of the imprinted sensor were all found to be satisfactory. Finally, the constructed electrode was successfully employed for determination of tramadol in real samples.
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