Encefalitis autoinmune por anticuerpos contra el receptor GABA-A: Caso clínico

Autoimmune encephalitis induced by antibodies against GABA -A receptorAmong autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements.A new variant, mediated by antibodies against the GABA -A receptor, was recently described.We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus.The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants.The laboratory tests initially detected anti-thyroid peroxidase antibodies which lead to the misdiagnosis of Hashimoto Encephalitis, which was ruled out after the detection of antibodies against GABA -A receptor.No malignancy was detected.