In vivo Evaluation of Antimicrobial Effect of Methanolic Extract of Chlorella vulgaris on Impetigo and Some Dermatophytes

IMPETIGO is one of the infectious superficial bacterial diseases and itstreatment with antimicrobial agents may cause serious problems. So, atest of new microbial infection-fighting natural compounds is necessary. Inthe present study, histological examinations of the experimental animalsrevealed the effectiveness and safety of Chlorella vulgaris methanolicextract ointment used in the treatment of impetigo, tinea corporis andcutaneous candidiasis without any side effects on skin tissues. In addition,examination of skin sections treated with C. Chlorella vulgaris extractpossessed no significant toxic effects. The skin appeared with normalepidermis as the keratinized fibers of stratum corneum were regularlyarranged, appeared condensed without any disruption. The dermisappeared normal with minimal inflammatory cellular to infiltrate withthe formation of hair follicles and sweat glands in comparison with a healthyskin. According to the chemical analyses of Chlorella vulgaris, theantimicrobial material was defined as a phenolic compound having thefollowing formula C14H17NO4 and the suggested structure could be 2- (1-hydroxy-2- (4-hydroxyphenyl)-2- methoxyethyl - 4- oxopentane nitrile.