Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans

线粒体 生物 细胞生物学
作者
Diana Guzman‐Villanueva,Volkmar Weissig
出处
期刊:Handbook of experimental pharmacology [Springer Science+Business Media]
卷期号:: 423-438 被引量:21
标识
DOI:10.1007/164_2016_37
摘要

Mitochondria, the powerhouse of the cell, have been known for many years for their central role in the energy metabolism; however, extensive progress has been made and to date substantial evidence demonstrates that mitochondria play a critical role not only in the cell bioenergetics but also in the entire cell metabolome. Mitochondria are also involved in the intracellular redox poise, the regulation of calcium homeostasis, and the generation of reactive oxygen species (ROS), which are crucial for the control of a variety of signaling pathways. Additionally, they are essential for the mitochondrial-mediated apoptosis process. Thus, it is not surprising that disruptions of mitochondrial functions can lead or be associated with human pathologies. Because of diseases like diabetes, Alzheimer, Parkinson's, cancer, and ischemic disease are being increasingly linked to mitochondrial dysfunctions, the interest in mitochondria as a prime pharmacological target has dramatically risen over the last decades and as a consequence a large number of agents, which could potentially impact or modulate mitochondrial functions, are currently under investigation. Based on their site of action, these agents can be classified as mitochondria-targeted and non-mitochondria-targeted agents. As a result of the continuous search for new agents and the design of potential therapeutic agents to treat mitochondrial diseases, terms like mitochondriotropics, mitochondriotoxics, mitocancerotropics, and mitocans have emerged to describe those agents with high affinity to mitochondria that exert a therapeutic or deleterious effect on these organelles. In this chapter, mitochondria-targeted agents and some strategies to deliver agents to and/or into mitochondria will be reviewed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
陈补天完成签到 ,获得积分10
刚刚
CipherSage应助慧灰huihui采纳,获得10
1秒前
乐观健柏完成签到,获得积分10
2秒前
4秒前
CodeCraft应助大橙子采纳,获得10
4秒前
量子星尘发布了新的文献求助10
5秒前
jeeya完成签到,获得积分10
6秒前
8秒前
科目三应助科研通管家采纳,获得10
8秒前
科目三应助科研通管家采纳,获得10
8秒前
伦语发布了新的文献求助10
8秒前
顾矜应助科研通管家采纳,获得10
8秒前
xuzj应助科研通管家采纳,获得10
8秒前
xuzj应助科研通管家采纳,获得10
8秒前
8秒前
NexusExplorer应助科研通管家采纳,获得10
8秒前
8秒前
8秒前
丘比特应助科研通管家采纳,获得10
9秒前
yull完成签到,获得积分10
9秒前
小巧书雪完成签到,获得积分10
12秒前
大大怪将军完成签到,获得积分10
13秒前
哈哈哈完成签到 ,获得积分0
13秒前
小怪完成签到,获得积分10
14秒前
爱吃泡芙完成签到,获得积分10
15秒前
白桃战士完成签到,获得积分10
16秒前
18秒前
qingchenwuhou完成签到 ,获得积分10
18秒前
XXX完成签到,获得积分10
19秒前
锡嘻完成签到 ,获得积分10
19秒前
20秒前
彗星入梦完成签到 ,获得积分10
20秒前
恋恋青葡萄完成签到,获得积分10
20秒前
隐形万言完成签到,获得积分10
22秒前
Time完成签到,获得积分10
22秒前
土木研学僧完成签到,获得积分10
23秒前
yjy完成签到 ,获得积分10
23秒前
A溶大美噶完成签到,获得积分10
23秒前
yar应助萨尔莫斯采纳,获得10
24秒前
Will发布了新的文献求助10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038201
求助须知:如何正确求助?哪些是违规求助? 3575940
关于积分的说明 11373987
捐赠科研通 3305747
什么是DOI,文献DOI怎么找? 1819274
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022