Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders

Background: Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune and inflammatory disorders. Virtually in most inflammatory diseases, immune response towards HSPs is developed. Keywords: Heat shock proteins (HSPs), inflammation, IL-10, molecular chaperon, necroptosis, NF-κB pathway, Tregs, TLR.