光催化
催化作用
镍
乙烯
过渡金属
配体(生物化学)
卤化物
选择性
发散合成
芳基
化学
光化学
组合化学
有机化学
光催化
烷基
受体
生物化学
作者
Jiesheng Li,Yixin Luo,Han Wen Cheo,Yu Lan,Jie Wu
出处
期刊:Chem
[Elsevier]
日期:2018-11-08
卷期号:5 (1): 192-203
被引量:108
标识
DOI:10.1016/j.chempr.2018.10.006
摘要
Divergent synthesis represents a powerful strategy for directly accessing different molecular scaffolds originating from the same starting materials. Access to different end products via transition-metal catalysis is conventionally achieved by ligand control. We herein demonstrate the use of ethylene feedstock and commercially available aryl halides to accomplish the divergent synthesis of 1,2-diarylethanes, 1,4-diarylbutanes, or 2,3-diarylbutanes in a highly selective fashion through the synergistic combination of nickel and photoredox catalysis. Mechanistic studies suggest that the observed selectivity was due to different active states of Ni(I) and Ni(0) modulated by Ru- and Ir-based photoredox catalysts, respectively. The ability to access different organometallic oxidation states via photoredox catalysis promises to inspire new perspectives for synergistic transition-metal-catalyzed divergent synthesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI