Purified ingredient-based high-fat diet is superior to chow-based equivalent in the induction of metabolic syndrome

Journal of Food BiochemistryVolume 43, Issue 2 e12717 FULL ARTICLE Purified ingredient-based high-fat diet is superior to chow-based equivalent in the induction of metabolic syndrome Hong Sheng Cheng, Hong Sheng Cheng School of Science, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorSonia Chew Wen Phang, Sonia Chew Wen Phang School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorSo Ha Ton, So Ha Ton School of Science, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorKhalid Abdul Kadir, Khalid Abdul Kadir School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorJoash Ban Lee Tan, Corresponding Author Joash Ban Lee Tan tan.ban.lee@monash.edu orcid.org/0000-0001-6623-2427 School of Science, Monash University Malaysia, Subang Jaya, Malaysia Correspondence Joash Ban Lee Tan, School of Science, Monash University Malaysia, 46150 Bandar Sunway, Subang Jaya, Selangor, Malaysia. Email: tan.ban.lee@monash.eduSearch for more papers by this author Hong Sheng Cheng, Hong Sheng Cheng School of Science, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorSonia Chew Wen Phang, Sonia Chew Wen Phang School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorSo Ha Ton, So Ha Ton School of Science, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorKhalid Abdul Kadir, Khalid Abdul Kadir School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, MalaysiaSearch for more papers by this authorJoash Ban Lee Tan, Corresponding Author Joash Ban Lee Tan tan.ban.lee@monash.edu orcid.org/0000-0001-6623-2427 School of Science, Monash University Malaysia, Subang Jaya, Malaysia Correspondence Joash Ban Lee Tan, School of Science, Monash University Malaysia, 46150 Bandar Sunway, Subang Jaya, Selangor, Malaysia. Email: tan.ban.lee@monash.eduSearch for more papers by this author First published: 04 November 2018 https://doi.org/10.1111/jfbc.12717Citations: 2 Funding information Ministry of Science, Technology and Innovation, Malaysia, Grant/Award Number: 02-02-10-SF0249 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The present study aimed to outline the physiological and metabolic disparity between chow- and purified ingredient-based high-fat diets and their efficacy in the induction of metabolic syndrome (MetS). Male, 3-week-old Sprague Dawley rats were randomly assigned to chow-based control diet, chow-based high-fat diet, purified control diet, and purified high-fat diet for 12 weeks. Physical and biochemical changes were documented. Chow-based diets, irrespective of the lipid content, resulted in significantly lower weight gain and organ weight compared to purified ingredient-based diets. Circulating insulin, total proteins, albumin, and certain lipid components like the triglycerides, total cholesterol, and high-density lipoprotein-cholesterol were also lower in the chow-based diet groups. Both chow- and purified high-fat diets induced central obesity, hypertension, and hyperglycaemia, but the latter was associated with earlier onset of the metabolic aberrations and additionally, dyslipidaemia. In conclusion, purified high-fat diet is a better diet for MetS induction in rats. Practical applications Modeling metabolic syndrome is commonly accomplished with the use of chow- or purified ingredient diets enriched with carbohydrates and/or lipids, but the differences and associated drawbacks are unclear. This study highlights that chow- or modified chow-based diets have a tendency to introduce unwanted metabolic changes which are inconsistent with the progression of metabolic syndrome. Thus, the use of these diets in metabolic disease study should be avoided. On the other hand, purified high-fat diet which can effectively induce the features of metabolic syndrome is highly recommended. CONFLICT OF INTEREST The authors declared that they have no conflict of interest. Citing Literature Volume43, Issue2February 2019e12717 RelatedInformation