再生医学
干细胞
间充质干细胞
细胞生物学
材料科学
免疫系统
人口
诱导多能干细胞
再生(生物学)
癌症研究
化学
免疫学
医学
生物
生物化学
胚胎干细胞
环境卫生
基因
作者
Alireza Rafieerad,Weiang Yan,Glen Lester Sequiera,Niketa Sareen,Ejlal Abu‐El‐Rub,Meenal Moudgil,Sanjiv Dhingra
标识
DOI:10.1002/adhm.201900569
摘要
Abstract Inflammation is tightly linked to tissue injury. In regenerative medicine, immune activation plays a key role in rejection of transplanted stem cells and reduces the efficacy of stem cell therapies. Next‐generation smart biomaterials are reported to possess multiple biologic properties for tissue repair. Here, the first use of 0D titanium carbide (Ti 3 C 2 ) MXene quantum dots (MQDs) for immunomodulation is presented with the goal of enhancing material‐based tissue repair after injury. MQDs possess intrinsic immunomodulatory properties and selectively reduce activation of human CD4 + IFN‐γ + T‐lymphocytes (control 87.1 ± 2.0%, MQDs 68.3 ± 5.4%) while promoting expansion of immunosuppressive CD4 + CD25 + FoxP3 + regulatory T‐cells (control 5.5 ± 0.7%, MQDs 8.5 ± 0.8%) in a stimulated lymphocyte population. Furthermore, MQDs are biocompatible with bone marrow‐derived mesenchymal stem cells and induced pluripotent stem cell‐derived fibroblasts. Finally, Ti 3 C 2 MQDs are incorporated into a chitosan‐based hydrogel to create a 3D platform with enhanced physicochemical properties for stem cell delivery and tissue repair. This composite hydrogel demonstrates increased conductivity while maintaining injectability and thermosensitivity. These findings suggest that this new class of biomaterials may help bridge the translational gap in material and stem cell‐based therapies for tissue repair and treatment of inflammatory and degenerative diseases.
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