GPX4
谷胱甘肽
纳米材料
活性氧
癌细胞
纳米技术
锰
材料科学
配体(生物化学)
癌症治疗
癌症治疗
化学
降级(电信)
氧气
纳米颗粒
芬顿反应
硅酸盐
生物物理学
表面改性
共价键
癌症
聚合
组合化学
毒品携带者
过氧化物酶
细胞毒性
药品
激进的
作者
Shuaifei Wang,Fangyuan Li,Ruirui Qiao,Xi Hu,Hongwei Liao,Lumin Chen,Jiahe Wu,Haibin Wu,Meng Zhao,Jianan Liu,Rui Chen,Xibo Ma,Dokyoon Kim,Jihong Sun,Thomas P. Davis,Chunying Chen,Jie Tian,Taeghwan Hyeon,Daishun Ling
出处
期刊:ACS Nano
[American Chemical Society]
日期:2018-11-29
卷期号:12 (12): 12380-12392
被引量:376
标识
DOI:10.1021/acsnano.8b06399
摘要
Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized via a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to T1-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics.
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