材料科学
PLGA公司
生物医学工程
再生(生物学)
光热效应
光热治疗
植入
体内
纳米技术
外科
纳米颗粒
医学
生物技术
生物
细胞生物学
作者
Liping Tong,Qing Liao,Yuetao Zhao,Hao Huang,Ang Gao,Wei Zhang,Xiaoyong Gao,Wei Wei,Min Guan,Paul K. Chu,Huaiyu Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2018-12-10
卷期号:193: 1-11
被引量:214
标识
DOI:10.1016/j.biomaterials.2018.12.008
摘要
Mild heat stimulation can promote the restoration of bone defects but unfortunately, the delivery of exo-hyperthermy into human body is not efficient enough. In this study, mild heat-induced osteogenesis with high efficacy is demonstrated on an osteoimplant composed of black phosphorus nanosheets and poly(lactic-co-glycolic acid) (BPs@PLGA) with the participation of near-infrared (NIR) light irradiation. BPs@PLGA with only 0.2 wt% BPs show the highly-efficient NIR photothermal response even when being covered by a biological tissue as thick as 7 mm. In addition, this composite is completely biodegradable and the final degradation products are harmless H2O, CO2 and PO43- which can serve as necessary bone ingredient. The BPs@PLGA specimen mediated by low intensity and periodic NIR irradiation can effectively up-regulate the expressions of heat shock proteins and finally promote osteogenesis in vitro and in vivo. Boasting good biodegradability and NIR-mediated osteogenetic performances, the BPs@PLGA implant has great potential in orthopedic applications and this study provides new insights into the design and fabrication of new-style osteoimplants which can be remotely controlled.
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