医学
破折号
危险系数
地中海饮食法
内科学
前瞻性队列研究
比例危险模型
2型糖尿病
队列研究
肝细胞癌
低风险
护士健康研究
置信区间
治疗饮食
糖尿病
精制谷物
血压
内分泌学
食品科学
全谷物
化学
操作系统
计算机科学
作者
Yanan Ma,Wanshui Yang,Tracey G. Simon,Stephanie A. Smith‐Warner,Teresa T. Fung,Jing Sui,Dawn Q. Chong,Trang VoPham,Jeffrey A. Meyerhardt,Deliang Wen,Edward L. Giovannucci,Andrew T. Chan,Xuehong Zhang
出处
期刊:Hepatology
[Wiley]
日期:2019-03-05
卷期号:70 (2): 577-586
被引量:67
摘要
Although adherence to healthy dietary guidelines has been associated with a reduced risk of several health outcomes, including cardiovascular diseases, type 2 diabetes, and some cancers, little is known about the role of dietary patterns in the development of hepatocellular carcinoma (HCC). We prospectively assessed the associations of three key commonly used a priori dietary patterns—the Alternative Healthy Eating Index‐2010 (AHEI‐2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH)—with risk of incident HCC in the Health Professionals Follow‐Up Study (HPFS) and the Nurses’ Health Study (NHS), two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires (FFQs). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. During up to 32 years of follow‐up, 160 incident HCC cases were identified. After adjustment for most HCC risk factors, participants in the highest tertile of Alternative Healthy Eating Index‐2010 (AHEI‐2010) had a multivariable HR of 0.61 (95% CI, 0.39‐0.95; P trend = 0.03), compared with those in the lowest tertile. There was a suggestive, but nonsignificant, inverse association for Alternate Mediterranean Diet (AMED; HR = 0.75; 95% CI, 0.49‐1.15; P trend = 0.18) and a null association for Dietary Approaches to Stop Hypertension (DASH; HR = 0.90; 95% CI, 0.59‐1.36; P trend = 0.61) in relation to the risk of HCC development. Conclusion: Our findings suggest that better adherence to the AHEI‐2010 may decrease the risk of developing HCC among U.S. adults. Future studies are needed to replicate our results, examine these associations in other populations, and elucidate the underlying mechanisms.
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