鲍曼不动杆菌
舒巴坦钠
美罗培南
医学
左氧氟沙星
呼吸机相关性肺炎
不动杆菌
抗菌剂
阿米卡星
微生物学
亚胺培南
抗药性
肺炎
抗生素
内科学
抗生素耐药性
生物
铜绿假单胞菌
细菌
遗传学
作者
Yuqin Huang,Quan Zhou,Wenguo Wang,Qiang Huang,Juan Liao,Junyi Li,Линг Лонг,Tao Ju,Quan Zhang,Hanqin Wang,Huaqiang Xu,TU Ming-li
标识
DOI:10.3389/fphar.2019.00092
摘要
Objective: To evaluate therapeutic efficacy of different combined antimicrobial treatments against acinetobacter baumannii ventilator-associated pneumonia (VAP). Methods: Clinical outcomes were retrospectively analyzed to elucidate the efficacy of four combined antimicrobial regimens. The chessboard and micro broth dilution methods determined the minimum inhibitory concentrations of four antiseptic drugs singly used and combined two drugs against 36 isolates of multi-drug resistant (MDR) acinetobacter baumannii. Results: The incidence of VAP was approximately 6.9% (237/3424) between January 1 2015 and December 31, and 35.9% (85/237) of the cases were caused by acinetobacter baumannii. Among these cases, 60 belonged to AB-VAP, for whom antimicrobial treatment plan was centralized and clinical data was complete. Moreover, all 60 strains of acinetobacter baumannii were MDR bacteria from reports microbiological laboratory. Resistance rate was lowest for amikacin (68.3%) and ampicillin sulbactam (71.7%). Resistance rate for imipenem increased from 63.2% to 90.9% during the three years. However, in these 60 cases of AB-VAP, the combination between 4 antibiotics was effective in most cases: the effective rate was 75%(18/24) for sulbactam combined with etilmicin, 71.4%(10/14) for sulbactam combined with levofloxacin, 72.7%(8/11) for meropenem combined with etilmicin, and 63.6%(7/11) for meropenem combined with levofloxacin. There was no statistical difference between four regimens(P>0.05). Sulbactam combined with etilmicin decreased 1/2 of MIC50 and MIC90 of sulbactam while the decreases in etilmicin were more obviously than single drug. When adopting meropenem combined with levofloxacin or etilmicin, the MIC of meropenem reduced to 1/2 of that in applying single drug. As for sulbactam or meropenem combined with levofloxacin, it also lessened the MIC50 of levofloxacin to 1/2 of that for single drug. FIC results suggested that the effects of four combined antimicrobial regimens were additive or unrelated. When sulbactam was combined with etimicin, the additive effect was 63.89%. Conclusion: Drug combination sensitivity test in vitro may be helpful for choosing antimicrobial treatment plans. Sulbactam or meropenem as the basis of treatment regimens can function as the alternatives against AB-VAP. Sulbactam combined with etimicin has been regarded as a recommended regimen in Suizhou, Hubei, China.
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