组织工程
肝组织
生物医学工程
材料科学
纳米技术
计算机科学
工程类
医学
内科学
作者
Tarun Agarwal,Bhuvaneshwaran Subramanian,Tapas K. Maiti
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2019-07-29
卷期号:5 (9): 4167-4182
被引量:35
标识
DOI:10.1021/acsbiomaterials.9b00745
摘要
Liver tissue engineering aims at the possibility of reproducing a fully functional organ for the treatment of acute and chronic liver disorders. Approaches in this field endeavor to replace organ transplantation (gold standard treatment for liver diseases in a clinical setting) with in vitro developed liver tissue constructs. However, the complexity of the liver microarchitecture and functionality along with the limited supply of cellular components of the liver pose numerous challenges. This review provides a comprehensive outlook onto how the physicochemical, mechanobiological, and spatiotemporal aspects of the substrates could be tuned to address current challenges in the field. We also highlight the strategic advancements made in the field so far for the development of artificial liver tissue. We further showcase the currently available prototypes in research and clinical trials, which shows the hope for the future of liver tissue engineering.
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