Cervical human papillomavirus (HPV) infection and associated genotypes in female patients with vulvar condyloma acuminatum from Shanghai area.

：ObjectiveTo studycervical HPV infection in female patients with vulvar condyloma acuminatum(CA)fromShanghai area.MethodsExfoliated cells were obtained from cervices and vulva lesions of CAof 194 patients.respectively.HPV genotyping was carried out in cell samples usingcapture-hybridization method and gene chip techniques.Results HPV was detected in vulvalesions of all the 194 patients.Among them,74.2%(144/194)were positive for lowrisk(LR)-HPV,and 25.8%(50/194)for high risk(HR)-HPV.A single HPV genotype(6 or 11)wasdetected in 136(94.4%)patients with LR-HPV.and mixed genotypes of LR-HPV and HR-HPV in46(86%)patients with HR.HPV.Of the 194 patients.85.6%(166/194)were complicated by cervicalHPV infection.including 119(61.4%)cases of LR-HPV and 46(23.7%)cases of HR-HPV,In the caseof HPV genotype.the consistence between CA lesions and cervix was 95.8%(159/166).Theprevalence of LR-HPV declined sequentially from subtype 11 to 6 and 53,and that of HR-HPVfrom subtype 16 to 18 followed by 52,31,45 and 58.Conclusions There is a high rate ofinfection with HR-HPV in female patients with CA.and nearly one quarter of these patientsare complicated by cervical HR-HPV infection.