Oligoreview of Non-Small Cell Lung Cancer Oligometastases

In this Oncology Scan, we summarize 3 recent, prospective, randomized studies that have explored the role of local consolidative therapy (LCT), and in some more specifically, stereotactic ablative radiation therapy (SABR), in the setting of oligometastatic non-small cell lung cancer and its impact on cancer outcomes and survival. The oligometastatic state generally refers to a situation with a limited number of metastases and where the possibility to extend survival may materialize from metastases-directed treatments. 1 Hellman S. Weichselbaum R.R. Oligometastases. J Clin Oncol. 1995; 13: 8-10 Crossref PubMed Google Scholar There is no consensus as to the exact definition of a "limited" number of metastases, although 3 or 5 are commonly considered to constitute the oligometastatic state. These 3 studies build on the published works of many institutions reporting both retrospective and prospective data exploring the role of LCT of primary tumors and metastases that have demonstrated encouraging evidence with respect to disease control and tolerability.