癌症
癌细胞
生物
调节器
活性氧
氧化应激
癌症研究
计算生物学
生物信息学
细胞生物学
基因
遗传学
生物化学
作者
Yang Liu,Fengchao Lang,Chunzhang Yang
标识
DOI:10.1016/j.pharmthera.2020.107664
摘要
Nuclear factor-erythroid 2-related factor 2 (NRF2) is a master regulator of a series of cytoprotective genes, which protects cells from stress conditions such as reactive oxygen species (ROS) and electrophiles. Besides its pivotal role in cellular physiology and stress response, several recent advances revealed that NRF2-governed pathways are extensively exploited in cancer cells, and play critical roles in granting growth advantage, supporting cancer metabolism, and promoting malignant transformation. In the present review, we focus on the regulatory mechanisms of NRF2 and its roles in cancer biology. We also discuss the value of targeting NRF2-associated pathways as a means of developing future cancer therapeutics.
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