Preclinical evaluation of the new GPRC5DxCD3 (JNJ-7564) bispecific antibody for the treatment of multiple myeloma

The prognosis of multiple myeloma (MM) patients who are refractory to all currently available therapies, including anti-CD38 monoclonal antibodies, remains poor, indicating that there is an unmet need for novel treatment strategies. Although data on G protein-coupled receptor 5D (GPRC5D) protein expression is scarce, RNA levels are selectively elevated in MM cell lines and primary MM cells. This makes GPRC5D an attractive target for the novel anti-myeloma JNJ-7564 bispecific antibody.