代谢组
生物
肠道菌群
杂食动物
微生物群
人类粪便
粪便
代谢组学
厚壁菌
人体微生物群
食品科学
细菌
生物化学
微生物学
生物信息学
遗传学
生态学
捕食
16S核糖体RNA
作者
Ceylan Tanes,Kyle Bittinger,Yuan Gao,Elliot S. Friedman,Lisa Nessel,Unmesha Roy Paladhi,Lillian Chau,Erika Panfen,Michael A. Fischbach,Jonathan Braun,Ramnik J. Xavier,Clary B. Clish,Hongzhe Li,Frederic D. Bushman,James D. Lewis,Gary D. Wu
标识
DOI:10.1016/j.chom.2020.12.012
摘要
Gut microbiota metabolites may be important for host health, yet few studies investigate the correlation between human gut microbiome and production of fecal metabolites and their impact on the plasma metabolome. Since gut microbiota metabolites are influenced by diet, we performed a longitudinal analysis of the impact of three divergent diets, vegan, omnivore, and a synthetic enteral nutrition (EEN) diet lacking fiber, on the human gut microbiome and its metabolome, including after a microbiota depletion intervention. Omnivore and vegan, but not EEN, diets altered fecal amino acid levels by supporting the growth of Firmicutes capable of amino acid metabolism. This correlated with relative abundance of a sizable number of fecal amino acid metabolites, some not previously associated with the gut microbiota. The effect on the plasma metabolome, in contrast, were modest. The impact of diet, particularly fiber, on the human microbiome influences broad classes of metabolites that may modify health.
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