Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner

内分泌学 生物 胎盘 性二态性 胎儿 内分泌系统 激素 细胞生物学 怀孕 遗传学
作者
Bethany R. L. Aykroyd,Simon J. Tunster,Amanda N. Sferruzzi‐Perri
出处
期刊:Journal of Endocrinology [Bioscientifica]
卷期号:246 (1): 93-108 被引量:31
标识
DOI:10.1530/joe-20-0128
摘要

The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable maternal physiological support of the pregnancy. In mice, these functions are performed by the labyrinth (Lz) and junctional (Jz) zones, respectively. Insulin-like growth factor 2 (Igf2) is an imprinted gene expressed by the conceptus that is important for promoting fetal growth and placenta formation. However, the specific role of Igf2 in the Jz in regulating placental endocrine function and fetal development is unknown. This study used a novel model to investigate the effect of conditional loss of Igf2 in the Jz (Jz-Igf2UE) on placental endocrine cell formation and the expression of hormones and IGF signaling components in placentas from female and male fetuses. Jz-Igf2UE altered gross placental structure and expression of key endocrine and signaling genes in a sexually dimorphic manner. The volumes of spongiotrophoblast and glycogen trophoblast in the Jz were decreased in placentas from female but not male fetuses. Expression of insulin receptor was increased and expression the MAPK pathway genes (Mek1, P38α) decreased in the placental Jz of female but not male fetuses. In contrast, expression of the type-1 and -2 IGF receptors and the MAPK pathway genes (H-ras, N-ras, K-ras) was decreased in the placental Jz from male but not female fetuses. Expression of the steroidogenic gene, Cyp17a1, was increased and placental lactogen-2 was decreased in the placenta of both sexes. In summary, we report that Jz-Igf2UE alters the cellular composition, IGF signaling components and hormone expression of the placental Jz in a manner largely dependent on fetal sex.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
fakte发布了新的文献求助10
刚刚
秋秋完成签到,获得积分10
刚刚
刚刚
NexusExplorer应助kyle采纳,获得10
刚刚
1秒前
bkagyin应助有Data发Paper采纳,获得10
1秒前
小天使海蒂发布了新的文献求助200
1秒前
大愤球发布了新的文献求助10
1秒前
summer发布了新的文献求助10
2秒前
2秒前
3秒前
吕蛋蛋发布了新的文献求助10
3秒前
5秒前
未知数发布了新的文献求助10
5秒前
6秒前
虚幻的凤发布了新的文献求助10
7秒前
8秒前
8秒前
10秒前
八大山人发布了新的文献求助10
10秒前
俊逸梦蕊发布了新的文献求助10
10秒前
幸福的冷安完成签到,获得积分10
10秒前
甜甜圈发布了新的文献求助10
11秒前
cyj990522完成签到 ,获得积分10
11秒前
YINLANRUI发布了新的文献求助10
12秒前
cangcang完成签到,获得积分10
13秒前
zhaojing9532完成签到,获得积分10
13秒前
不爱科研完成签到 ,获得积分10
13秒前
戴先森发布了新的文献求助10
14秒前
英姑应助落寞怜雪采纳,获得10
14秒前
共享精神应助小何同学采纳,获得10
14秒前
Marybaby发布了新的文献求助10
15秒前
CipherSage应助ee采纳,获得10
15秒前
爆米花应助kiminonawa采纳,获得10
16秒前
16秒前
kuroo应助高兴的彩虹采纳,获得10
18秒前
18秒前
顺利的飞荷完成签到,获得积分0
19秒前
芙蓉发布了新的文献求助30
20秒前
20秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184989
求助须知:如何正确求助?哪些是违规求助? 2835313
关于积分的说明 8004338
捐赠科研通 2497758
什么是DOI,文献DOI怎么找? 1333120
科研通“疑难数据库(出版商)”最低求助积分说明 636776
邀请新用户注册赠送积分活动 604219