Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner

内分泌学 生物 胎盘 性二态性 胎儿 内分泌系统 激素 细胞生物学 怀孕 遗传学
作者
Bethany R. L. Aykroyd,Simon J. Tunster,Amanda N. Sferruzzi‐Perri
出处
期刊:Journal of Endocrinology [Bioscientifica]
卷期号:246 (1): 93-108 被引量:31
标识
DOI:10.1530/joe-20-0128
摘要

The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable maternal physiological support of the pregnancy. In mice, these functions are performed by the labyrinth (Lz) and junctional (Jz) zones, respectively. Insulin-like growth factor 2 (Igf2) is an imprinted gene expressed by the conceptus that is important for promoting fetal growth and placenta formation. However, the specific role of Igf2 in the Jz in regulating placental endocrine function and fetal development is unknown. This study used a novel model to investigate the effect of conditional loss of Igf2 in the Jz (Jz-Igf2UE) on placental endocrine cell formation and the expression of hormones and IGF signaling components in placentas from female and male fetuses. Jz-Igf2UE altered gross placental structure and expression of key endocrine and signaling genes in a sexually dimorphic manner. The volumes of spongiotrophoblast and glycogen trophoblast in the Jz were decreased in placentas from female but not male fetuses. Expression of insulin receptor was increased and expression the MAPK pathway genes (Mek1, P38α) decreased in the placental Jz of female but not male fetuses. In contrast, expression of the type-1 and -2 IGF receptors and the MAPK pathway genes (H-ras, N-ras, K-ras) was decreased in the placental Jz from male but not female fetuses. Expression of the steroidogenic gene, Cyp17a1, was increased and placental lactogen-2 was decreased in the placenta of both sexes. In summary, we report that Jz-Igf2UE alters the cellular composition, IGF signaling components and hormone expression of the placental Jz in a manner largely dependent on fetal sex.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Cecilia完成签到,获得积分10
1秒前
1秒前
2秒前
上官若男应助hao采纳,获得10
5秒前
nono发布了新的文献求助10
5秒前
haapy发布了新的文献求助10
5秒前
文武完成签到,获得积分20
6秒前
ChaiN完成签到,获得积分10
6秒前
鲤鱼千风完成签到 ,获得积分10
8秒前
8秒前
8秒前
9秒前
小趴菜完成签到,获得积分10
10秒前
烟花应助Whisper采纳,获得10
10秒前
尊敬的半梅应助kmyang采纳,获得10
12秒前
icebear发布了新的文献求助10
12秒前
菜菜完成签到,获得积分10
13秒前
Liu发布了新的文献求助10
13秒前
Yael完成签到,获得积分10
13秒前
13秒前
nono完成签到,获得积分10
14秒前
Jiangnj发布了新的文献求助10
15秒前
皛皛完成签到,获得积分10
15秒前
Yael发布了新的文献求助10
15秒前
snowball完成签到,获得积分10
16秒前
辛勤钧完成签到,获得积分10
17秒前
ForestEcho发布了新的文献求助10
19秒前
dzvd发布了新的文献求助10
19秒前
20秒前
20秒前
小王完成签到 ,获得积分10
21秒前
21秒前
卜颖滨完成签到,获得积分10
22秒前
干净的媚颜关注了科研通微信公众号
22秒前
Whisper给Whisper的求助进行了留言
22秒前
23秒前
思源应助积极的身影采纳,获得10
23秒前
李健应助DE2022采纳,获得10
23秒前
猫咪老师应助执行正义采纳,获得30
25秒前
辛勤钧发布了新的文献求助10
25秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3182829
求助须知:如何正确求助?哪些是违规求助? 2832989
关于积分的说明 7991986
捐赠科研通 2495147
什么是DOI,文献DOI怎么找? 1331321
科研通“疑难数据库(出版商)”最低求助积分说明 636271
邀请新用户注册赠送积分活动 603328