Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner

内分泌学 生物 胎盘 性二态性 胎儿 内分泌系统 激素 细胞生物学 怀孕 遗传学
作者
Bethany R. L. Aykroyd,Simon J. Tunster,Amanda N. Sferruzzi‐Perri
出处
期刊:Journal of Endocrinology [Bioscientifica]
卷期号:246 (1): 93-108 被引量:31
标识
DOI:10.1530/joe-20-0128
摘要

The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable maternal physiological support of the pregnancy. In mice, these functions are performed by the labyrinth (Lz) and junctional (Jz) zones, respectively. Insulin-like growth factor 2 (Igf2) is an imprinted gene expressed by the conceptus that is important for promoting fetal growth and placenta formation. However, the specific role of Igf2 in the Jz in regulating placental endocrine function and fetal development is unknown. This study used a novel model to investigate the effect of conditional loss of Igf2 in the Jz (Jz-Igf2UE) on placental endocrine cell formation and the expression of hormones and IGF signaling components in placentas from female and male fetuses. Jz-Igf2UE altered gross placental structure and expression of key endocrine and signaling genes in a sexually dimorphic manner. The volumes of spongiotrophoblast and glycogen trophoblast in the Jz were decreased in placentas from female but not male fetuses. Expression of insulin receptor was increased and expression the MAPK pathway genes (Mek1, P38α) decreased in the placental Jz of female but not male fetuses. In contrast, expression of the type-1 and -2 IGF receptors and the MAPK pathway genes (H-ras, N-ras, K-ras) was decreased in the placental Jz from male but not female fetuses. Expression of the steroidogenic gene, Cyp17a1, was increased and placental lactogen-2 was decreased in the placenta of both sexes. In summary, we report that Jz-Igf2UE alters the cellular composition, IGF signaling components and hormone expression of the placental Jz in a manner largely dependent on fetal sex.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
可爱的函函应助维周之桢采纳,获得10
1秒前
高贵剑鬼关注了科研通微信公众号
1秒前
Owen应助memory采纳,获得10
2秒前
Cloud发布了新的文献求助30
3秒前
3秒前
韩麒嘉完成签到,获得积分10
3秒前
田様应助漂亮的秋天采纳,获得10
3秒前
西酞普绿发布了新的文献求助30
4秒前
same发布了新的文献求助10
4秒前
xjcy应助aefs采纳,获得10
4秒前
zsrrrrrr完成签到 ,获得积分10
6秒前
也一样完成签到,获得积分10
6秒前
科研通AI2S应助123采纳,获得10
7秒前
王肖完成签到 ,获得积分10
8秒前
Cloud完成签到,获得积分10
8秒前
科研通AI2S应助顺心紫翠采纳,获得10
9秒前
10秒前
10秒前
zsrrrrrr关注了科研通微信公众号
10秒前
11秒前
13秒前
Zoe完成签到,获得积分10
13秒前
13秒前
14秒前
熊大发布了新的文献求助10
15秒前
Jasper应助Chloe采纳,获得10
16秒前
17秒前
高贵剑鬼发布了新的文献求助10
18秒前
HR发布了新的文献求助10
18秒前
汉堡包应助随便采纳,获得10
18秒前
乐乐应助张梦真采纳,获得10
19秒前
19秒前
顾矜应助熊大采纳,获得10
20秒前
Lemon_Code应助朴实凝阳采纳,获得10
20秒前
明理的旭尧给张琛的求助进行了留言
20秒前
金刚经应助朴实凝阳采纳,获得10
20秒前
满意冰露发布了新的文献求助10
21秒前
23秒前
刘丽梅完成签到 ,获得积分10
23秒前
Rain发布了新的文献求助10
23秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3195319
求助须知:如何正确求助?哪些是违规求助? 2844145
关于积分的说明 8048793
捐赠科研通 2508780
什么是DOI,文献DOI怎么找? 1341026
科研通“疑难数据库(出版商)”最低求助积分说明 639078
邀请新用户注册赠送积分活动 608150