Igf2 deletion alters mouse placenta endocrine capacity in a sexually dimorphic manner

内分泌学 生物 胎盘 性二态性 胎儿 内分泌系统 激素 细胞生物学 怀孕 遗传学
作者
Bethany R. L. Aykroyd,Simon J. Tunster,Amanda N. Sferruzzi‐Perri
出处
期刊:Journal of Endocrinology [Bioscientifica]
卷期号:246 (1): 93-108 被引量:31
标识
DOI:10.1530/joe-20-0128
摘要

The placenta regulates materno-fetal nutrient transfer and secretes hormones that enable maternal physiological support of the pregnancy. In mice, these functions are performed by the labyrinth (Lz) and junctional (Jz) zones, respectively. Insulin-like growth factor 2 (Igf2) is an imprinted gene expressed by the conceptus that is important for promoting fetal growth and placenta formation. However, the specific role of Igf2 in the Jz in regulating placental endocrine function and fetal development is unknown. This study used a novel model to investigate the effect of conditional loss of Igf2 in the Jz (Jz-Igf2UE) on placental endocrine cell formation and the expression of hormones and IGF signaling components in placentas from female and male fetuses. Jz-Igf2UE altered gross placental structure and expression of key endocrine and signaling genes in a sexually dimorphic manner. The volumes of spongiotrophoblast and glycogen trophoblast in the Jz were decreased in placentas from female but not male fetuses. Expression of insulin receptor was increased and expression the MAPK pathway genes (Mek1, P38α) decreased in the placental Jz of female but not male fetuses. In contrast, expression of the type-1 and -2 IGF receptors and the MAPK pathway genes (H-ras, N-ras, K-ras) was decreased in the placental Jz from male but not female fetuses. Expression of the steroidogenic gene, Cyp17a1, was increased and placental lactogen-2 was decreased in the placenta of both sexes. In summary, we report that Jz-Igf2UE alters the cellular composition, IGF signaling components and hormone expression of the placental Jz in a manner largely dependent on fetal sex.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郭二发布了新的文献求助10
3秒前
SciGPT应助斯文的萝莉采纳,获得10
3秒前
隐形曼青应助科研通管家采纳,获得10
3秒前
ding应助科研通管家采纳,获得30
3秒前
852应助科研通管家采纳,获得10
4秒前
明天完成签到 ,获得积分10
4秒前
英俊的铭应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
无花果应助科研通管家采纳,获得10
4秒前
充电宝应助科研通管家采纳,获得10
4秒前
汉堡包应助科研通管家采纳,获得10
4秒前
今后应助科研通管家采纳,获得10
4秒前
不倦应助科研通管家采纳,获得10
4秒前
ding应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
5秒前
ah完成签到,获得积分10
7秒前
xin完成签到,获得积分10
7秒前
minghanl发布了新的文献求助30
7秒前
三水台完成签到,获得积分10
8秒前
王美贤完成签到,获得积分20
8秒前
四喜丸子应助文件撤销了驳回
9秒前
10秒前
10秒前
科研通AI2S应助An采纳,获得10
10秒前
Garfield完成签到 ,获得积分10
11秒前
JamesPei应助加菲丰丰采纳,获得10
12秒前
Hello应助嗷嗷嗷啊采纳,获得10
13秒前
烟花应助干净秋双采纳,获得10
14秒前
小鱼儿发布了新的文献求助10
15秒前
秀丽烨霖应助义气的莛采纳,获得10
16秒前
20秒前
20秒前
20秒前
不配.应助听说采纳,获得10
21秒前
六瓶瓶发布了新的文献求助10
21秒前
李子完成签到,获得积分10
21秒前
21秒前
冷静灵竹完成签到 ,获得积分10
22秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189181
求助须知:如何正确求助?哪些是违规求助? 2838612
关于积分的说明 8020271
捐赠科研通 2501388
什么是DOI,文献DOI怎么找? 1335575
科研通“疑难数据库(出版商)”最低求助积分说明 637634
邀请新用户注册赠送积分活动 605685