Qingpeng ointment for treafment of chronic eczema: a Meta analysis

Objective To investigate the efficacy and safety of Qingpeng ointment treating adult chronic eczema. Methods In May 2018, cases of chronic eczema were searched in databases of Chongqing Weipu (2000-2017), China Knowledge Resource Integrated Database (2000-2017) and Wanfang (2000-2017) through Nanjing Medical University Library website in the Department of Dermatology, Suzhou Science and Technology Town Hospital. RevMan5.3 software provided by Cochrane collaboration was used for Meta-analysis. To ensure data reliability, only the documents from Grade three hospitals were included. The experimental group was treated with Qingpeng ointment, while the control group was treated with weakly potent glucocorticosteroid, such as glucocorticoid cream, or moderately potent glucocorticosteroid, such as hydrocortisone butyrate cream, fluticasone propionate, halometasone and triamcinolone urea cream. Results Totally, 7 randomized controlled trials, among which 258 patients in the trial group and 242 patients in the control group were included. The odds ratio (OR) values of Qingpeng ointment relative to glucocorticoid group at 2 and 4 weeks were 0.95 (0.52, 1.72) and 0.80 (0.29, 2.25) respectively, showing no significant difference (P=0.54 and P=0.60, respectively, 95% Confidence Interval). Compared with hydrocortisone butyrate treating group, the OR value was 0.75 (0.31, 1.82). And compared with moderately potent mometasone furoate, there was no significant difference in two-week and four-week treatment groups 0.99 (0.50, 1.95), 1.10 (0.18, 6.53) (P=0.38 and P=0.36). No obvious adverse reactions were found in Qingpeng ointment treated group. Conclusions Qingpeng ointment is safe and effective in treating chronic eczema. There is no significant difference between Qingpeng ointment treating group and glucocorticosteroid treating group. Qingpeng ointment can be used as a safe external medicine for the treatment of chronic eczema. Key words: Eczema; Randomized controlled trial; Meta-analysis; Glucocorticoids; External preparations; Qing Peng ointment