透明质酸
自愈水凝胶
甲基丙烯酸
材料科学
肿胀 的
生物相容性
透明质酸酶
真皮
高分子化学
核化学
共聚物
化学
复合材料
聚合物
生物化学
酶
冶金
解剖
生物
医学
遗传学
作者
Yulong Ding,Hong Bo Zhang,Rui Yin,Wenjun Zhang
出处
期刊:Materials Science Forum
日期:2020-03-01
卷期号:982: 59-66
被引量:2
标识
DOI:10.4028/www.scientific.net/msf.982.59
摘要
Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility and enzymatic degradability. In this paper a photo-crosslinking double-network hyaluronic acid-based hydrogel dressing was proposed. Hyaluronic acid can be UV-crosslinked by modification with methacrylic anhydride (HA-MA) and disulfide-crosslinked by modification with 3,3'-dithiobis (propionylhydrazide) (DTP) (HA-SH). The mixings of these two materials at different ratios were produced. All the samples can be quickly gelled at 365 nm for 10 s. The rheological tests show that the storage modulus (G') of the double network (HA-SH/HA-MA) hydrogel is increased with the increase of HA-SH content. The HA-SH/HA-MA hydrogel has porous structure, high swelling ratio and Controlled degradation rate. In vitro degradation tests show that the ratio of HA-SH/HA-MA ratio was 9:1 (S9M1) in 100 U/ml hyaluronidase (Hase) degraded by 89.91±2.26% at 11d. The cytocompatibility of HA-SH/HA-MA hydrogels was proved by Live/Dead stainings and CCK-8 assays in the human dermis fibroblasts (HDF) cells test. All these results highlight the biological potential of the HA-SH/HA-MA hydrogels for DFU intervention.
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