抗菌肽
抗菌剂
生物
细菌
先天免疫系统
微生物学
抗生素
人类病原体
免疫系统
遗传学
作者
Alexander M. Cole,Tomas Ganz
出处
期刊:BioTechniques
[Future Science Ltd]
日期:2000-10-01
卷期号:29 (4): 822-831
被引量:56
摘要
Antimicrobial peptides are innate host defense molecules that have a direct effect on bacteria, fungi and enveloped viruses. They are found in evolutionarily diverse species ranging from prokaryotes and plants to invertebrate and vertebrate animals. Humans express several families of antimicrobial peptides in myeloid cells and on various epithelial surfaces where they are poised to defend against pathogens. Recently, antimicrobial peptides from animals and plants have served as templates for the design of new therapeutic antibiotics. This review provides an introduction to the biology of human antimicrobial peptides, followed by a more detailed discussion of their isolation from tissues and biological fluids, their purification by gel electrophoresis and chromatography and assays of their antimicrobial activities.
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