Preparation of n‐butoxy(13C2‐acetic) acid, 1‐n‐butoxy‐2‐hydroxy (13C2‐ethane), (n‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐d7)acetic acid, and 2‐(n‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐d7)ethanol

Abstract ( n ‐Butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )acetic acid ( 1 ) and 2‐( n ‐butoxy‐2′,2′,3′,3′,4′,4′,4′‐ d 7 )ethanol ( 2 ) have been prepared in high yield from n ‐butanol‐2,2,3,3,4,4,4‐ d 7 . n ‐ Butoxy( 13 C 2 ‐acetic) acid ( 3 ) and 1‐ n ‐butoxy‐2‐hydroxy( 13 C 2 ‐ethane) ( 4 ) have also been synthesized using bromoacetic‐ 13 C 2 acid as the source of labelled carbon. The main complication in the development of the process was partial conversion of butoxyacetic acid to butyl butoxyacetate during GC analysis, which hampered evaluation of trial reactions.