Plasma uric acid concentrations are reduced by fenofibrate: A systematic review and meta-analysis of randomized placebo-controlled trials

类降脂药 非诺贝特 医学 尿酸 内科学 安慰剂 高尿酸血症 随机对照试验 体质指数 贝扎纤维 内分泌学 痛风 阿司匹林 胆固醇 胃肠病学 病理 替代医学
作者
Giuseppe Derosa,Pamela Maffioli,Amirhossein Sahebkar
出处
期刊:Pharmacological Research [Elsevier]
卷期号:102: 63-70 被引量:65
标识
DOI:10.1016/j.phrs.2015.09.012
摘要

Hyperuricaemia increases the risk of gout, but it is also a risk factor for cardiovascular diseases. To conduct a systematic review and meta-analysis of relevant randomized clinical trials to ascertain the effect size of fibrates in modulating plasma uric acid concentrations. Medline (http://www.ncbi.nlm.nih.gov/pubmed), SCOPUS, Web of Science and Google Scholar databases were searched. Studies were included if they met the following inclusion criteria: (i) being a randomized placebo-controlled trial with either parallel or cross-over design, (ii) investigating the impact of fibrate therapy on plasma uric acid concentrations, (iii) presentation of sufficient information on uric acid values at baseline and at the end of follow-up in each group or providing the net change values. The following data were extracted: (1) first author's name; (2) year of publication; (3) study location; (4) study design; (5) number of participants in the fibrate and placebo groups; (6) type and dose of fibrate; (7) duration of treatment; (8) age, gender and body mass index (BMI) of study participants; (9) baseline levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, high-sensitivity C-reactive protein (hs-CRP) and glucose; (10) systolic and diastolic blood pressure; and (11) data regarding baseline and follow-up uric acid. There was a significant reduction in plasma uric acid concentrations following fenofibrate therapy. Few eligible studies, and most had small population sizes. Fenofibrate, but not bezafibrate is effective in reducing serum acid uric levels.
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