己酮可可碱
阿霉素
药理学
药品
化学
医学
化疗
内科学
作者
Grzegorz Gołuński,Agnieszka Borowik,Natalia Derewońko,Anna Kawiak,Michał Rychłowski,Anna Woziwodzka,Jacek Piosik
出处
期刊:Biochimie
[Elsevier]
日期:2016-04-01
卷期号:123: 95-102
被引量:19
标识
DOI:10.1016/j.biochi.2016.02.003
摘要
Anticancer drug doxorubicin is commonly used in cancer treatment. However, drug's severe side effects make toxicity reduction important matter. Another biologically active aromatic compound, pentoxifylline, can sequester aromatic compounds in stacking complexes reducing their bioactivity. This work deals with the problem of alleviating doxorubicin side effects by pentoxifylline. We employed a wide spectrum of prokaryotic and eukaryotic cellular assays. In addition, we used the doxorubicin-pentoxifylline mixed association constant to quantitatively assess pentoxifylline influence on the doxorubicin mutagenic activity. Obtained results indicate strong protective effects of pentoxifylline towards doxorubicin, observed on bacteria and human keratinocytes with no such effects observed on the cancer cells. It may be hypothesized that, considering much shorter half-life of pentoxifylline than doxorubicin, simultaneous administration of doxorubicin and pentoxifylline will lead to gradual release of doxorubicin from complexes with pentoxifylline to reach desired therapeutic concentration. Proposed results shed light on the possible doxorubicin chemotherapy modification and its side effects reduction without the loss of its therapeutic potential.
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