Chemical Constituents and Anti-inflammatory Activities of a Streptosporangium hygroscopicus n. sp.

To study the chemical constituents and the inflammatory activities of the cultured filaments of a Streptosporangium hygroscopicus n.sp..Several chromatographic methods were used to separate the chemical constituents,of which structures were identified by NMR,IR and MS.The anti-inflammatory activities of compounds 1,2,4 and 5 were observed in rats with carrageenin-induced toe swelling experiments.Five compounds have been isolated from the Streptosporangium hygroscopicus n.sp..Their structures were identified as formononetin(1),N-acetyl-2-(4-hydroxxy phen yl) ethylamine(2),fumalic acid(3),3,4,5-trimethyl-1,2-benzenediol(4),7,3'-dihydroxy-4'-methoxyflavone(5).Compounds 1,2,4 and 5 could inhibit carrageenin-induced toe swelling in rats at 15 mg /(kg·d),The inhibition ratio was 47.3%,16.8%,13.6% and 50.4%.Compounds 1、4 and 5 were isolated from this streptosporangium sp for the first time.Compound 1 and 5 possess strong anti-inflammatory activities.