Salvianolic Acid Effects of TNF Alpha,MMP - 2 /TIMP - 2 Expression in the Atrial Fibrillation Rat Model Randomized Controlled Study

[Objective]To observe Dan phenolic acids on atrial fibrillation rats peripheral blood matrix metalloproteinases,tissue matrix metalloproteinases inhibitory factor(MMP-2 / TIMP-2),tumor necrosis factor alpha(TNF alpha) expression.[Methods]The calcium chloride-acetylcholine mixture made mold,40 SD rats were randomly remove 10 as blank group.30 acetylcholine-calcium chloride(Ach-CaCl2) copy mixture tail vein injection animal models of atrial fibrillation for 4 weeks,typical atrial fibrillation in ECG modeling success.As part of death in rats,the 24 successful model in rats model group by block randomisation method random,verapamil group,Salvianolic acid group,8 / group,blank group randomized minus 2.Modeling 2d,verapamil group were given verapamil 20mg / kg d orally;the salvianolic acid treatment group was given Danshen injection of acid 4mg / kg d orally;model group and the control group with an equal amount of distilled water orally.1 times / d,for 4 weeks,free drinking water,given a fixed feed.ELISA assay of serum MMP-2 / TIMP-2,TNF-alpha changes.[Results]The model group TNF alpha,MMP-2 level higher,lower TIMP 2;Dan phenolic acid treatment group,verapamil intervention group were decreased peripheral blood TNF alpha,MMP-2 level,elevated TIMP-2 level,and Dan phenolic acid group effect of verapamil group.[Conclusion]Dan phenolic acids af can be improved through the rat heart muscle cells in the process of reconstruction of damage degree,and treatment of atrial fibrillation.