破译
生物
DNA条形码
计算生物学
疾病
进化生物学
生物信息学
医学
病理
作者
Vijay G. Sankaran,Jonathan S. Weissman,Leonard I. Zon
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2022-10-13
卷期号:378 (6616)
被引量:36
标识
DOI:10.1126/science.abm5874
摘要
Cellular barcodes are distinct DNA sequences that enable one to track specific cells across time or space. Recent advances in our ability to detect natural or synthetic cellular barcodes, paired with single-cell readouts of cell state, have markedly increased our knowledge of clonal dynamics and genealogies of the cells that compose a variety of tissues and organs. These advances hold promise to redefine our view of human disease. Here, we provide an overview of cellular barcoding approaches, discuss applications to gain new insights into disease mechanisms, and provide an outlook on future applications. We discuss unanticipated insights gained through barcoding in studies of cancer and blood cell production and describe how barcoding can be applied to a growing array of medical fields, particularly with the increasing recognition of clonal contributions in human diseases.
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