Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

The multifunctional nanoparticles mediated a photothermal/chemodynamic/CO combination therapy, which can be activated by NIR laser and H 2 O 2 at tumor sites, providing a promising strategy for cancer treatment. • Co-loading Re 2 (CO) 10 and ultra-small Cu 2-x Se into mesoporous polydopamine for combining multiple strategies. • NIR laser and H 2 O 2 triggered simultaneous CO controlled release and ROS generation. • Photothermal/chemodynamic/CO therapies for breast cancer combination treatment. The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re 2 (CO) 10 and ultra-small Cu 2-x Se into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H 2 O 2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo . The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.