生物膜
格氏链球菌
微生物学
牙周炎
化学
牙龈卟啉单胞菌
细菌
病菌
抗生素耐药性
慢性牙周炎
共生细菌
抗生素
纳米技术
生物
材料科学
医学
共生
牙科
遗传学
作者
Qinghua Cao,Xiang Xiao,Chengcheng Tao,Rui Shi,Rui Lv,Ruochen Guo,Xinyi Li,Junshan Sun,Xin Liu,Jian Liu
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:11 (16): 5680-5693
被引量:2
摘要
As a key pathogen of periodontitis, P. gingivalis requires support of the initial colonizing bacterium (S. gordonii preferably) to form symbiotic biofilms on gingival tissues with enhanced antibiotic resistance. Here, we report a new strategy to treat periodontitis biofilms with S. gordonii membrane-coated H2O2 self-supplied nanocomposites (ZnO2/Fe3O4@MV NPs) in a "Jenga" style. Integration of our special MV coatings enables selectively enhanced internalization of the cargos in S. gordonii, thus inducing severe damage to the foundational bacterial layer and collapse/clearance of symbiotic biofilms consequently. This strategy allows us to clear the symbiotic biofilms of S. gordonii and P. gingivalis with active hydroxyl radicals (˙OH) derived from ZnO2-Fe3O4@MV NPs in a H2O2 self-supplied, nanocatalyst-assisted manner. This "Jenga-style" treatment provides a cutting-edge proof of concept for the removal of otherwise robust symbiotic biofilms of periodontitis where the critical pathogens are difficult to target and have antibiotic resistance.
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