新烟碱
益达胺
静水椎实螺
桃蚜
二烯
化学
立体化学
生物
杀虫剂
有机化学
植物
农学
蚜虫
生态学
天然橡胶
蜗牛
作者
Yiping Wang,Xiao Zhang,Yijin Kong,Wu‐Lin Yang,Zhiping Xu,Jiagao Cheng,Xusheng Shao,Xiaoyong Xu,Zhong Li
标识
DOI:10.1021/acs.jafc.3c01802
摘要
Neonicotinoid insecticides acting on the insect nicotinic acetylcholine receptors (nAChRs) play an essential role in contemporary pest control. In the present study, a series of novel neonicotinoid analogues with conjugated diene were synthesized. Bioassays indicated that compounds A3 and A12 had LC50 values of 1.26 and 1.24 mg/L against Myzus persicae, respectively, which were comparable to that of imidacloprid (IMI, LC50 = 0.78 mg/L). Density functional theory (DFT) calculations were performed to explain the differences in the insecticidal activities of target compounds. Molecular docking results indicate that compounds A3 and A12 interact favorably with Lymnaea stagnalis AChBP. The hydrolysis experiments confirmed that the stability of compounds A3 and A12 was enhanced in water.
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