Exudate‐Induced Gelatinizable Nanofiber Membrane with High Exudate Absorption and Super Bactericidal Capacity for Bacteria‐Infected Wound Management

Abstract Invasion of bacteria and continuous oozing of exudate are significant causes of interference with the healing of infected wounds. Therefore, an exudate‐induced gelatinizable and near‐infrared (NIR)‐responsive nanofiber membrane composed of polyvinyl alcohol (PVA), carboxymethyl chitosan (CMC), and Fe‐doped phosphomolybdic acid (Fe‐PMA) with exceptional exudate absorption capacity and potent bactericidal efficacy is developed and denoted as the PVA‐FP‐CMC membrane. After absorbing exudate, the fiber membrane can transform into a hydrogel membrane, forming coordination bonds between the Fe‐PMA and CMC. The unique exudate‐induced gelation process imparts the membrane with high exudate absorption and retention capability, and the formed hydrogel also traps the bacteria that thrive in the exudate. Moreover, it is discovered for the first time that the Fe‐PMA exhibits an enhanced photothermal conversion capability and photocatalytic activity compared to the PMA. Therefore, the presence of Fe‐PMA provides the membrane with a photothermal and photodynamic therapeutic effect for killing bacteria. The PVA‐FP‐CMC membrane is proven with a liquid absorption ratio of 520.7%, a light‐heat conversion efficiency of 41.9%, high‐level generation of hydroxyl radical (•OH) and singlet oxygen ( 1 O 2 ), and a bacterial killing ratio of 100% for S. aureus and 99.6% for E. coli . The treatment of infected wounds on the backs of rats further confirms the promotion of wound healing by the PVA‐FP‐CMC membrane with NIR irradiation. Overall, this novel functional dressing for the synergistic management of bacteria‐infected wounds presents a promising therapeutic strategy for tissue repair and regeneration.